Allegra during Pregnancy, is it safe?

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Cetirizine and loratadine, two more recent antihistamines, may also be secure. Additionally, there is a corticosteroid nasal spray that can be used safely while pregnant. However, a small risk of birth defects in the abdominal wall has been associated with one of the most popular decongestants, pseudoephedrine. Pseudoephedrine shouldn’t be used during the first three months of pregnancy.

Many people with allergies take antihistamines for relief. According to studies, it’s safe to take a number of over-the-counter allergy medications while pregnant, including

Be mindful of the medications you’re taking. If possible, avoid allergy medications entirely during your first trimester.

But most importantly, consult your physician before using any allergy medications at any time while you are pregnant.

Take a moment before taking your usual medication if you experience the dreaded sniffles, sneezing, and congestion of seasonal allergies while pregnant. Some allergy medications can be harmful to growing babies.

After the first trimester, some oral antihistamines like Zyrtec (cetrizine), Benadryl (diphenhydramine), Chlor-Trimeton (chlorpheniramine), Claritin (loratadine), and Allegra (fexofenadine) seem to be safe. Therefore, there is currently no evidence of harm that they have caused.

Main Outcomes and Measures Major birth defects and spontaneous abortion. Preterm birth, small for gestational age (SGA), and stillbirth were considered secondary outcomes. The prevalence odds ratios (ORs) of major birth defects, preterm birth, and SGA were estimated using logistic regression, and the hazard ratios (HRs) of spontaneous abortion and stillbirth were estimated using Cox proportional hazards regression.

The prevalence ORs for the matched analyses of any major birth defect and the exploratory analysis of major birth defect subgroups are shown in Figure 2. In 118 pregnancies, major birth defects in the infants were discovered (4 0%) with fexofenadine use compared with 112 pregnancies (3. 8%) with cetirizine use (prevalence OR, 1. 06; 95% CI, 0. 81-1. 37), corresponding to an absolute risk difference (ARD) of 0. 02% (95% CI, −0. 08% to 0. 12%) per 1000 pregnancies. When fexofenadine was compared to cetirizine, specific subgroups of major birth defects were analyzed, but no significantly higher risks were found.

Dr. Torp-Pedersen disclosed receiving grants from Bayer and Novo Nordisk in addition to the work that was submitted. No other disclosures were reported. References.

We found no statistically significant differences between the use of fexofenadine and cetirizine during pregnancy in the risk of serious birth defects, spontaneous abortion, preterm birth, SGA, and stillbirth in this nationwide cohort study. Additionally, sensitivity analyses that included contrasting the use of fexofenadine with the use of loratadine during pregnancy and with pregnancies that were not exposed to fexofenadine during pregnancy but had previously used the drug produced outcomes that were similar to those of the primary analyses.

By subtracting the gestational age from the date of birth or the abortive result (such as a spontaneous abortion or stillbirth), we were able to estimate the pregnancy onset (i.e., the first day of the last menstrual period). With the help of this knowledge, we were able to monitor the cohort beginning with pregnancy. We eliminated pregnancies with multiple records on the same dates and pregnancies with implausible or incomplete gestational age information. While analyses of spontaneous abortion and stillbirth were based on all pregnancies, analyses of major birth defects, preterm birth, and SGA were based on pregnancies that resulted in live births. Fexofenadine Exposure.

Ask The Doctor with Dr. Rene Leon – Is it safe to take allergy medications during pregnancy?

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