Can You Take Baby Aspirin While Pregnant

Low dose aspirin can lower a woman’s risk for preeclampsia and other pregnancy-related hypertensive disorders, according to the American College of Obstetricians and Gynecologists and the Society of Maternal-Fetal Medicine.

If your doctor advises taking low-dose aspirin while you are pregnant, start taking 81mg of aspirin each day at bedtime between 12 and 16 weeks into the pregnancy. Keep taking it until you are at least 36 weeks pregnant.

For pregnant women with specific medical conditions like high blood pressure, diabetes, and kidney disease, low-dose aspirin is advised. Pregnant women with higher risks for hypertensive disorders, such as first-time mothers, those over 35, and those carrying twins or triplets, may also benefit.

Very little is known about how low dose aspirin affects male reproduction. Men who visited an infertility clinic and took unprescribed low-dose aspirin at various doses and frequencies for at least six months were the subjects of one study. According to the study, sperm quantity and quality decreased, especially in those who took more aspirin. In general, men are not thought to need to stop taking low-dose aspirin before attempting to conceive a child with their partner. However, men receiving fertility treatment may wish to consult with their medical professionals to determine whether they should stop taking aspirin.

Aspirin is also known as acetylsalicylic acid. Similar to other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Motrin®) and naproxen (Aleve®), it is a common prescription and over-the-counter drug. Aspirin reduces inflammation, fever, and pain. Aspirin is helpful in treating or preventing conditions like heart attacks and strokes because it can prevent blood clots.

There are few studies on the long-term effects of pregnant women taking low doses of aspirin on their unborn children. However, research has not revealed a higher risk of physical or mental development issues in infants at 18 months of age. In comparison to children who were not exposed to low dose aspirin during pregnancy, children up to the age of five who were born very early (before 33 weeks) and who were exposed to low dose aspirin during pregnancy did not show any differences in their learning or behavior.

OTIS/MotherToBaby encourages inclusive and person-centered language. Although mothers are still mentioned in our name, we are updating our resources to use more inclusive language. When the terms “mother” or “maternal” are used, they refer to a pregnant person. When the terms “father” or “paternal” are used, it refers to a sperm donor.

It is not anticipated that taking low-dose aspirin as prescribed by a healthcare professional will result in any other pregnancy issues. According to studies, low dose aspirin may help some women become pregnant by increasing blood flow to the uterus and reducing swelling or inflammation there. Additionally, research suggests that those who are at high risk for preeclampsia (dangerously high blood pressure and pregnancy complications) may benefit from taking low dose aspirin. However, pregnant women should only take low-dose aspirin if their doctor advises them to.

Contraindications to Aspirin Use During Pregnancy

There are few absolute contraindications to aspirin therapy 27. Low-dose aspirin should not be administered to patients who have a history of aspirin allergy (such as urticaria) or hypersensitivity to other salicylates due to the risk of anaphylaxis. Low-dose aspirin is also contraindicated in patients with known NSAID hypersensitivity due to the significant cross-sensitivity between aspirin and these medications. Low-dose aspirin exposure in people with nasal polyps has the potential to cause fatal bronchoconstriction and should be avoided. The same holds true for asthma patients who have experienced acute bronchospasm brought on by aspirin. A history of internal bleeding, active peptic ulcer disease, other causes of gastrointestinal or genitourinary bleeding, and severe liver dysfunction are relative contraindications to low-dose aspirin. Reye syndrome has been reported rarely (less than 1%) in children younger than 18 years who are given aspirin while recovering from viral illnesses, particularly influenza and chickenpox If there is obstetric bleeding or risk factors for obstetric bleeding, the decision to continue taking low-dose aspirin should be made case-by-case.

The majority of trials using low-dose aspirin during pregnancy have started treatment between 12 weeks and 28 weeks of gestation, with the exception of studies looking at how to prevent early pregnancy loss. Only when treatment is initiated before 16 weeks have some researchers reported the best outcomes 28 29 30 31 Preeclampsia only slightly decreased when low-dose aspirin was started after 16 weeks, according to a recent meta-analysis of aggregate data from 45 randomized trials (RR, 0). 81; CI, 0. 66–0. 99) but significant reductions in severe preeclampsia (RR, 0. 47; CI, 0. 26–0. 83) and fetal growth restriction (RR, 0. 56; CI, 0. 44–0. When low-dose aspirin was started before 16 weeks, 70) were demonstrated 31 Another meta-analysis found a decrease in preterm preeclampsia only in the subgroup of patients who started taking aspirin before 16 weeks of pregnancy at a daily dose of 100 mg or more (RR, 0). This meta-analysis included data from the recent Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence-Based Preeclampsia Prevention trial. 33; 95% CI, 0. 19–0. 57) 30. The positive effects of low-dose aspirin, however, were consistently observed in another study that pooled individual data from 31 high-quality randomized trials, regardless of when treatment began (before or after 16 weeks of gestation) 32.

Stopping low-dose aspirin before giving birth doesn’t appear to have any advantages. Pregnancy-specific study protocols have varied; some have stopped low-dose aspirin at 36 weeks’ gestation while others have kept taking it up until delivery 14 33 34 35. Excessive maternal or fetal bleeding has not been linked to the timing of the discontinuation. Similarly, taking low-dose aspirin without taking any other anticoagulants does not preclude using neuraxial blockade 36. Some patients who are taking low-dose aspirin initially seek medical attention. It is unknown if first-trimester exposure is linked to beneficial maternal outcomes or negative fetal effects.

Baby aspirin to help prevent preeclampsia? Here’s what we know

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