Study shows how low-protein intake during pregnancy can cause renal problems in offspring

According to the authors, between 10% and 13% of the world population suffer from chronic kidney disease, a gradual irreversible loss of renal function that is associated with high blood pressure and cardiovascular disorder

“In humans, these links were first observed after World War Two as a result of what’s known as the ‘Dutch famine’ [Hongerwinter], when the Nazis blocked food supplies to the Netherlands. Scientific studies showed that babies born to women who starved while pregnant in this period were underweight and developed high blood pressure, alterations in response to stress, heart problems, propensity to diabetes, and increased insulin resistance,” said Boer, who is president of DOHaD Brazil.

The relationship between maternal health during pregnancy and child development has been the subject of extensive research in recent years, particularly in the area of developmental origins of health and disease (DOHaD).

The article “Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus” (doi: 10.1371/journal.pone.0246289) by Letícia de Barros Sene, Wellerson Rodrigo Scarano, Adriana Zapparoli, José Antônio Rocha Gontijo and Patrícia Aline Boer is at: journals.plos.org/plosone/article?id=10.1371/journal.pone.0246289.

In a study published in PLOS ONE, researchers affiliated with the University of Campinas (UNICAMP) in the state of São Paulo, Brazil, discovered the cause of the problem at the molecular level and its link to epigenetic phenomena (changes in gene expression due to environmental factors such as stress, exposure to toxins or malnutrition, among others).

Protein Intake & Pregnancy Weight Gain

There are numerous practical and reliable methods for preventing pregnancy weight gain. This article will explain how protein can help you gain the appropriate amount of weight for your body and developing baby, even though it won’t cover weight gain fundamentals like what to anticipate and healthy ranges. You can find out which foods and lifestyle choices will best support healthy weight gain for your particular pregnancy with the aid of an integrative ob/gyn.

The three types of food that will assist your body in gaining the ideal amount of weight for you and your unborn child are:

  • Adequate amounts of protein. This keeps you feeling satisfied, provides micro- and macronutrients, plus it can keep cravings at bay and prevent overeating.
  • Low-glycemic carbohydrates. This keeps blood sugar levels from swinging wildly in either direction, and studies show that a low glycemic diet significantly lessens high pregnancy weight gain.
  • Mindful eating. Plan your meals around nutrient-dense, whole foods as much as possible. Listen to hunger and fullness cues, have healthy snacks readily available, and allow your body grace as it changes to meet the needs of you and your growing baby.
  • We acknowledge the following individuals and organizations for their help and support with this study: Dr. For the handling and upkeep of the experimental model, Dr. José Martn Garca Serván; the Animal Care Facility (Bioterio) of the Neurobiology Institute, UNM; Deisy Gasca Martnez, for her assistance in the UNM Neurobiology Institute’s Behavioral Analysis Unit; Felipe Santoyo Telles, of CUSUR-University of Guadalajara; and Ana Patricia Grajeda Figueroa, of CUSUR-University of Guadalajara; for their support in the statistical analysis; and The TEACHER PROFESSIONAL DEVELOPMENT PROGRAM (PRODEP) 2019–2021 (UDG–CA–700, ID–CA–19053) was acknowledged for its support.

    Contrarily, in the LPHC group of pregnant rats as compared to the nonpregnant rats, the VAT concentration decreased. Intragroup comparisons in the group exposed to the LPHC diet showed an increase of 600 and 610% on days 8G and 15G ( vs and vs. , when contrasted with the non-pregnant group on the LPHC diet In addition, we observed an increase of 200% in pregnant rats on day 15G, compared to the pregnant rats on day 3G ( vs ). Figure 5(a) depicts the visceral fat concentration in both early and late pregnancy in female rats, both of which were not pregnant.

    Contrary to non-pregnant rats, pregnant rats did not exhibit significant differences on EE during either light or dark periods in either the early or late stages of pregnancy (Figures 3(e) and 3(f)). The EE varied between 80 and 90 kcal in the control group and between 70 and 80 kcal in the LPHC group during the dark period. In late pregnancy, we noticed that the LPHC group had lower EE on hour 2 of the light period (compared to ), when compared with the control group.

    Rats who were pregnant in the control group displayed a decrease in RQ rhythmicity during the night. This finding indicates that lipid oxidation occurred in the control group during both the light- and dark-phases. Rats that were pregnant and those that were not showed different energy metabolisms, according to the LPHC group. Figure 4(b) depicts the LPHC group’s diurnal oxidation as shifting from lipids to carbohydrates. The LPHC group displayed a significant increase in the diurnal rhythmicity of the RQ at hour 9 in pregnant rats during the early stages of pregnancy (the value was 0). 9) (), when compared to the control group (Figure 4(b)). Comparing the LPHC group to the control group at hours 15, 16, 17, and 18 during the dark period, we saw an increase in the RQ rhythmicity (the value ranged from 1 to 1). 03), indicating carbohydrate oxidation.

    Variations in food and water intake were present in the control group both during and after pregnancy. Both the control group and the LPHC group experienced these variations in food intake (Figures 1(a) and 1(b)). Regarding body weight, we observed an increase trend of approximately 20%, compared to the LPHC group when the pregnancy started, but in the following 20 days, throughout pregnancy, we observed weight gain of 25% (Figure 2(b)) Rats in the control diet nonpregnant (CNP) group ate 45 to 80 kcal of food daily and drank 20 to 60 ml of water daily. At days 11, 17, 19, and 20G (110 and 115 kcal/d), the pregnant rats fed the control diet (CP) tended to consume more calories. This group consumed 35 to 60 ml of water per day, with a decrease at day 14G (70 ml/d) (Figures 1(a)–1(d)).

    Importance of Protein for Weight Gain during Pregnancy | What to eat and how?

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